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Products Details
Product Description
– EGFR/C797S-IN-1 is a potent EGFR-C797S inhibitor with an IC50 value of 0.128 µM. EGFR/C797S-IN-1 shows anti-proliferative activity and anti-tumor activity. EGFR/C797S-IN-1 inhibits the expression of p-EGFR in a dose-dependent manner[1].
Web ID
– HY-152019
Shipping
– Room temperature
Molecular Formula
– C28H30N4O3
References
– [1]Dou D, et al. Discovery and optimization of 4-anilinoquinazoline derivatives spanning ATP binding site and allosteric site as effective EGFR-C797S inhibitors. Eur J Med Chem. 2022 Dec 15;244:114856.
CAS Number
– 2378188-21-5
Molecular Weight
– 470.56
SMILES
– COC1=C(C=C2N=CN=C(C2=C1)NC3=CC=C(C=C3)OC4=CC=CC=C4)OCC5CCN(CC5)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Isoform
– EGFR/ErbB1/HER1
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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