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Products Details
Product Description
– E07 aptamer is an aptamer that targets human epidermal growth factor receptor (hEGFR). E07 aptamer can compete with EGF for binding, binds to a novel epitope on EGFR. E07 aptamer binds to cells expressing EGFR, blocks receptor autophosphorylation, and prevents proliferation of tumor cells in three-dimensional matrices. E07 aptamer can be used for tomor disease research[1].
Web ID
– HY-149517
Shipping
– Room temperature
Molecular Formula
– C25H18N4O2
References
– [1]Li N, et al. Inhibition of cell proliferation by an anti-EGFR aptamer. PLoS One. 2011;6(6):e20299. doi: 10.1371/journal.pone.0020299. Epub 2011 Jun 8.
Molecular Weight
– 406.44
SMILES
– O=C1NC2=C(C=C(C)C=C2)C(N3N=NC(C(C4=CC=CC=C4)=O)=C3C5=CC=CC=C5)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
