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Products Details
Product Description
– Edatrexate (CGP 30694), as known as 10-Ethyl-10-deazaaminopterin, is Methotrexate (HY-14519) analog, exhibits antitumor activity against MTX-resistant tumors. Edatrexate is an antifolate antimetabolite, can be used for reasearch of non-small-cell lung cancer, breast cancer, non-Hodgkin’s lymphoma, and cancer of the head and neck[1][2].
Web ID
– HY-13617
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H25N7O5
References
– [1]Grant SC, et al. Edatrexate, an antifolate with antitumor activity: a review. Cancer Invest. 1993;11(1):36-45. |[2]Sirotnak FM, et al. Markedly improved efficacy of edatrexate compared to methotrexate in a high-dose regimen with leucovorin rescue against metastatic murine solid tumors. Cancer Res. 1993 Feb 1;53(3):587-91.
CAS Number
– 80576-83-6
Molecular Weight
– 467.48
SMILES
– O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(C(CC2=NC3=C(N)N=C(N)N=C3N=C2)CC)C=C1)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Antifolate
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
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