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Products Details
Product Description
– EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor[1]. Small molecule-agent conjugate (SMDC)[2].
Web ID
– HY-114306
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C111H156N22O43S2
References
– [1]Leamon CP, et al. Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications. J Pharmacol Exp Ther. 2011 Feb;336(2):336-43.|[2]Zhuang C, et al. Small molecule-drug conjugates: A novel strategy for cancer-targeted treatment. Eur J Med Chem. 2019 Feb 1;163:883-895.
CAS Number
– 1096702-14-5
Molecular Weight
– 2550.68
SMILES
– [{Ggu}-QEQEQC]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Antifolate
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
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