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Ebselen
$50 – $210
Products Details
Product Description
– Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker[1][2]. Ebselen potently inhibits Mpro (IC50=0.67 μM) and COVID-19 virus (EC50=4.67 μM)[3].Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity[4][5].
Web ID
– HY-13750
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C13H9NOSe
References
– [1]Jin Z, et al. Structure of M<sup>pro</sup> from COVID-19 virus and discovery of its inhibitors. Nature. 2020 Apr 9.|[2]Liang Q, et al. Electrical Stimulation Degenerated Cochlear Synapses Through Oxidative Stress in NeonatalCochlear Explants. Front Neurosci. 2019 Oct 14;13:1073.|[3]H Sies, et al. Ebselen, a Selenoorganic Compound as Glutathione Peroxidase Mimic|[4]Hanavan PD, et al. Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines. Oncotarget. 2015 Jul 30;6(21):18418-28.|[5]Thenin-Houssier S, et al. Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2195-208.|[6]Singh N, et al. A safe lithium mimetic for bipolar disorder. Nat Commun. 2013;4:1332. doi: 10.1038/ncomms2320.
CAS Number
– 60940-34-3
Molecular Weight
– 274.18
Compound Purity
– 99.58
SMILES
– O=C1N(C2=CC=CC=C2)[Se]C3=C1C=CC=C3
Clinical Information
– Phase 3
Research Area
– Cancer; Infection; Inflammation/Immunology; Neurological Disease
Solubility
– DMSO : 50 mg/mL (ultrasonic)
Target
– Calcium Channel;HIV;Phosphatase;Virus Protease
Isoform
– HIV-1
Pathway
– Anti-infection;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
