E7016

$500$4,500

Products Details

Product Description

– E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo through the inhibition of DNA repair. E7016 acts as a potential anticancer agent[1][2].

Web ID

– HY-13540

Storage Temperature

– 4°C (Powder, protect from light)

Shipping

– Room Temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C20H19N3O3

References

– [1]Andrea L Russo, et al. In vitro and in vivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016. Clin Cancer Res. 2009 Jan 15;15(2):607-12.|[2]W George Lai, et al. A Baeyer-Villiger oxidation specifically catalyzed by human flavin-containing monooxygenase 5. Drug Metab Dispos. 2011 Jan;39(1):61-70.

CAS Number

– 902128-92-1

Molecular Weight

– 349.38

Compound Purity

– 98.46

SMILES

– O=C1NN=C2C3=C1C=CC=C3OC4=CC=C(CN5CCC(O)CC5)C=C42

Clinical Information

– Phase 2

Research Area

– Cancer

Solubility

– DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)

Target

– PARP

Isoform

– PARP

Pathway

– Cell Cycle/DNA Damage;Epigenetics

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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