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Products Details
Product Description
– E6446 is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD)[1][2][3].
Web ID
– HY-12756
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C27H35N3O3
Citations
– Infect Immun. 2019 Dec 17;88(1):e00697-19.|Oxid Med Cell Longev. 2019 Apr 28;2019:6527638. |Cell Commun Signal. 2023 Sep 30;21(1):268.|Patent. US20210388060A1.|Research Square Preprint. 2021 Mar.|Vet Microbiol. 2017 Aug;207:56-62.
References
– [1]Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.|[2]Franklin BS, et al. Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3689-94.|[3]Wang W, et al. Identification of novel SCD1 inhibitor alleviates nonalcoholic fatty liver disease: critical role of liver-adipose axis. Cell Commun Signal. 2023 Sep 30;21(1):268.
CAS Number
– 1219925-73-1
Molecular Weight
– 449.59
SMILES
– C1(C2=CC=C(OCCCN3CCCC3)C=C2)=NC4=CC=C(OCCCN5CCCC5)C=C4O1
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Stearoyl-CoA Desaturase (SCD);Toll-like Receptor (TLR)
Isoform
– TLR7;TLR9
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
