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(E/Z)-BIO-acetoxime
$74
Only 1000 item(s) left in stock.
Products Details
Product Description
– (E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selective GSK-3α/β inhibitor, with an IC50 of 10 nM. (E/Z)-BIO-acetoxime shows more than 200-flod selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B (IC50=2.4, 4.3, 63 μM)[1].
Web ID
– HY-114903
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C18H12BrN3O3
References
– [1]Meijer L, et, al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10(12):1255-66.
CAS Number
– 740841-15-0
Molecular Weight
– 398.21
SMILES
– CC(O/N=C1/C(NC2=C1C=CC=C2)=C3C(NC4=C3C=CC(Br)=C4)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– CDK;GSK-3
Isoform
– CDK1;CDK2;CDK5;GSK-3α;GSK-3β
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
