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Product Description
– (E)-Mcl-1 inhibitor 7 (Example 34) is a Mcl-1 inhibitor (Ki: <1 nM, IC50: <500 nM). (E)-Mcl-1 inhibitor 7 can be used for research of cancers[1].
Web ID
– HY-145825A
Shipping
– Room temperature
Molecular Formula
– C34H42ClN3O7S
References
– [1]Zhuo, Jincong, et al. Preparation of spiro-sulfonamide derivatives as inhibitors of myeloid cell leukemia-1 (MCL-1) protein for the treatment of cancer. Patent. WO2020097577.
CAS Number
– 2417463-86-4
Molecular Weight
– 672.23
SMILES
– ClC1=CC=C([C@@]2(CCC3)CN4C5=CC(S(=O)(NC(C(C)(OC/C=C[C@@H]([C@@]6([H])[C@](CC6)([H])C4)OC(N(C)C)=O)C)=O)=O)=CC=C5OC2)C3=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Bcl-2 Family
Isoform
– Mcl-1
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
