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Products Details
Product Description
– (E)-3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis[1][2].
Web ID
– HY-10082A
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C7H9N5S
References
– [1]Finch RA, et al. Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv Enzyme Regul. 1999;39:3-12. |[2]Enyedy ÉA ,et al. Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation. Dalton Trans. 2020 Dec 8;49(46):16887-16902.
CAS Number
– 200933-27-3
Molecular Weight
– 195.24
SMILES
– NC1=CC=CN=C1/C=N/NC(N)=S
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– DNA/RNA Synthesis
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
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