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Dyclonine (hydrochloride)
$55 – $92
Products Details
Product Description
– Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC50 of 35 µM for ALDH2 and 76 µM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local anesthetic that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain[1][2][3].
Web ID
– HY-B0364A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C18H28ClNO2
References
– [1]Okazaki S, et al. Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells. Oncotarget. 2018 Sep 18;9(73):33832-33843. |[2]FLORESTANO HJ, et al. Antimicrobial properties of dyclonine hydrochloride, a new topical anesthetic. J Am Pharm Assoc Am Pharm Assoc. 1956 May;45(5):320-5. |[3]Khanna M, et al. Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases. J Biol Chem. 2011 Dec 16;286(50):43486-94.
CAS Number
– 536-43-6
Molecular Weight
– 325.87
Compound Purity
– 99.86
SMILES
– O=C(C1=CC=C(OCCCC)C=C1)CCN2CCCCC2.Cl
Clinical Information
– Launched
Research Area
– Cancer; Infection
Solubility
– DMSO : ≥ 25 mg/mL|H2O : 50 mg/mL (ultrasonic)
Target
– Aldehyde Dehydrogenase (ALDH);Bacterial;Fungal
Isoform
– ALDH2;ALDH3
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
