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DuP 734
$250 – $2,000
Products Details
Product Description
– DuP 734 is a sigma receptor antagonist. DuP 734 is a selective and potent sigma and 5-HT2 receptor ligand with weak affinity for D2 receptors. DuP 734 may have antipsychotic activity without the liability of motor side effects typical of neuroleptics[1][2][3].
Web ID
– HY-136281
Storage Temperature
– 4°C (Powder, stored under nitrogen, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C17H23BrFNO
References
– [1]L Cook, et al. DuP 734 [1-(cyclopropylmethyl)-4-(2′(4”-fluorophenyl)-2′- Oxoethyl)piperidine HBr], a Potential Antipsychotic Agent: Preclinical Behavioral Effects. J Pharmacol Exp Ther. 1992 Dec;263(3):1159-66.|[2]M Watanabe, et al. [<sup>3</sup>H]1-(cyclopropylmethyl)-4-(2-(4-fluorophenyl)-2-oxoethyl) Piperidine HBr (DuP 734). A Selective Ligand for Sigma Receptors in Mouse Brain in Vivo. J Pharmacol Exp Ther. 1993 Sep;266(3):1541-8.|[3]R P Kapil, et al. Dose and Species Dependent Pharmacokinetics of a Novel Sigma Receptor Antagonist, DuP 734. Res Commun Mol Pathol Pharmacol. 1995 Apr;88(1):3-20.
CAS Number
– 135135-87-4
Molecular Weight
– 356.27
Compound Purity
– 98.82
SMILES
– FC1=CC=C(C(CC2CCN(CC3CC3)CC2)=O)C=C1.[H]Br
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 250 mg/mL (ultrasonic)|H2O : ≥ 100 mg/mL
Target
– Sigma Receptor
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
