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Products Details
Product Description
– DS21150768 is a potent, orally active HPK1 inhibitor. DS21150768 shows potent activity to enhance T-cell function. DS21150768 has anticancer effects[1].
Web ID
– HY-157149
Shipping
– Room temperature
Molecular Formula
– C36H32F2N6O2
References
– [1]Genzui Setsu, et al. Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models. Eur J Pharmacol. 2023 Nov 8:961:176184.
Molecular Weight
– 618.68
SMILES
– FC1=CC=C(N2C(C(C(NC3=CC=C(C4=C(N)N=CC(C5=CC(C)=NC(C)=C5)=C4)C=C3)=O)=C(NCC6(C7)CC7(F)C6)C=C2)=O)C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MAP4K
Isoform
– MAP4K1/HPK1
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
