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Droxinostat
SKU
HY-13267-1 mg
Category Reference compound
Tags Apoptosis;Cell Cycle/DNA Damage;Epigenetics, Apoptosis;HDAC, Cancer
$30 – $734
Products Details
Product Description
– Droxinostat (NS 41080) is a histone deacetylase (HDAC) inhibitor. Droxinostat selectively inhibits HDAC3, HDAC6, and HDAC8 with IC50 values of 16.9 μM, 2.47 μM, and 1.46 μM, respectively. Droxinostat can be used for the research of hepatocellular carcinoma (HCC)[1][2].
Web ID
– HY-13267
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C11H14ClNO3
References
– [1]Liu J, et al. Droxinostat, a Histone Deacetylase Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cell Lines via Activation of the Mitochondrial Pathway and Downregulation of FLIP. Transl Oncol. 2016 Feb;9(1):70-8.|[2]Wood TE et al. Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010 Jan;9(1):246-56.
CAS Number
– 99873-43-5
Molecular Weight
– 243.69
Compound Purity
– 99.60
SMILES
– ClC1=CC=C(C(C)=C1)OCCCC(NO)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 150 mg/mL
Target
– Apoptosis;HDAC
Isoform
– HDAC3;HDAC6;HDAC8
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.