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Drotaverine-d10 (hydrochloride)
Products Details
Product Description
– Drotaverine-d10 (hydrochloride) is the deuterium labeled Drotaverine hydrochloride. Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3′,5′-cyclic adenosine monophosphate. Drotaverine hydrochloride exhibits in vivo antispasmodic efficacy without anticholinergic effects[1][2].
Web ID
– HY-108974S
Shipping
– Room temperature
Molecular Formula
– C24H22D10ClNO4
References
– [1]Patai Z, Guttman A, Mikus EG. Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine. Pharmacology. 2018;101(3-4):163-169. |[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
Molecular Weight
– 444.03
SMILES
– [2H]C([2H])(C([2H])([2H])[2H])OC1=CC2=C(C=C1OC([2H])(C([2H])([2H])[2H])[2H])CCN/C2=CC3=CC=C(OCC)C(OCC)=C3.Cl
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Calcium Channel;Isotope-Labeled Compounds;Phosphodiesterase (PDE)
Pathway
– Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.