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Products Details
Product Description
– Drotaverine-d10 (hydrochloride) is the deuterium labeled Drotaverine hydrochloride. Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3′,5′-cyclic adenosine monophosphate. Drotaverine hydrochloride exhibits in vivo antispasmodic efficacy without anticholinergic effects[1][2].
Web ID
– HY-108974S
Shipping
– Room temperature
Molecular Formula
– C24H22D10ClNO4
References
– [1]Patai Z, Guttman A, Mikus EG. Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine. Pharmacology. 2018;101(3-4):163-169. |[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
Molecular Weight
– 444.03
SMILES
– [2H]C([2H])(C([2H])([2H])[2H])OC1=CC2=C(C=C1OC([2H])(C([2H])([2H])[2H])[2H])CCN/C2=CC3=CC=C(OCC)C(OCC)=C3.Cl
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Calcium Channel;Isotope-Labeled Compounds;Phosphodiesterase (PDE)
Pathway
– Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;Others
Product type
– Isotope-Labeled Compounds
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