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Products Details
Product Description
– DPP-4-IN-8 (compound 27) is a potent and selective DPP4 (dipeptidyl peptidase 4) inhibitor, with a Ki of 0.96 μM. DPP-4-IN-8 blocks the dipeptidase activity of DPP4 in both Caco-2 and HepG-2 cells. DPP-4-IN-8 also dose-dependently suppresses the expression levels of the chemokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β)[1].
Web ID
– HY-155027
Shipping
– Room temperature
Molecular Formula
– C16H12ClNO6
References
– [1]Li CQ, et al. Licochalcone A Derivatives as Selective Dipeptidyl Peptidase 4 Inhibitors with Anti-Inflammatory Effects. J Nat Prod. 2023 Jul 28;86(7):1824-1831.
Molecular Weight
– 349.72
SMILES
– [O-][N+](C1=CC(C(/C=C/C2=C(OC)C=C(O)C(Cl)=C2)=O)=CC=C1O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Dipeptidyl Peptidase;Interleukin Related;TNF Receptor
Isoform
– DPP-4;IL-1;IL-6
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
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