Products Details

Product Description

– DPP-4/GPR119 modulator 2 (Compound 20i) is a dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist with an IC50 of 0.22 μM for DPP-IV and an EC50 of 0.95 μM for GPR119. DPP-4/GPR119 modulator 2 can be used for diabetes research[1]. DPP-4/GPR119 modulator 2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Web ID

– HY-146469

Shipping

– Room temperature

Applications

– Metabolism-sugar/lipid metabolism

Molecular Formula

– C30H40N8O3

References

– [1]Li G, et al. The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119. Eur J Med Chem. 2020 Feb 15;188:112017.

CAS Number

– 2010927-65-6

Molecular Weight

– 560.69

SMILES

– CC#CCN1C(N2CCC[C@H](C2)N)=NC3=C1C(N(C(N3C)=O)CCCN4CCC(CC4)C(NC5=CC=CC=C5)=O)=O

Clinical Information

– No Development Reported

Research Area

– Metabolic Disease

Solubility

– 10 mM in DMSO

Target

– Dipeptidyl Peptidase;GPR119

Isoform

– DPP-4

Pathway

– GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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