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Products Details
Product Description
– DPNB-ABT594 is a nitrobenzyl-caged ABT594 (HY-14316A) and activates nAChRs containing the α4β2 subunits with good selectivity than the α7 subunit. DPNB-ABT594 can be used to map the distribution of nAChRs on neurons of the medial habenula (MHb) and helps to gain a deeper understanding of the nAChR‐mediated Ca2+ signalling in the MHb[1].
Web ID
– HY-131001
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C31H46ClN3O11
References
– [1]Stefan Passlick, et al. Optical Probing of Acetylcholine Receptors on Neurons in the Medial Habenula With a Novel Caged Nicotine Drug Analogue.J Physiol. 2018 Nov;596(22):5307-5318.
Molecular Weight
– 672.16
SMILES
– ClC1=NC=C(OC[C@@H]2N(C(C3=CC(OCCOCCOCCOC)=C(OCCOCCOCCOC)C=C3[N+]([O-])=O)C)CC2)C=C1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– nAChR
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
