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DOPE-mPEG (MW 2000)
$55 – $90
Products Details
Product Description
– DOPE-mPEG (MW 2000) is a phospholipid polydisperse PEG (or DOPE liposome), can be used for preparation of targeted delivery of liposomal drug and giant unilamellar vesicles (GUVs). DOPE-mPEG (MW 2000) significantly reduces the pH-sensitivity of the liposome in a concentration dependent manner[1][2][3].
Web ID
– HY-W440988
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– N/A
References
– [1]Shin J, et al. Acid-labile mPEG-vinyl ether-1,2-dioleylglycerol lipids with tunable pH sensitivity: synthesis and structural effects on hydrolysis rates, DOPE liposome release performance, and pharmacokinetics. Mol Pharm. 2012 Nov 5;9(11):3266-76.|[2]Su WC, et al. Pulsatile Gating of Giant Vesicles Containing Macromolecular Crowding Agents Induced by Colligative Nonideality. J Am Chem Soc. 2018 Jan 17;140(2):691-699.|[3]Xu H, et al. Enhanced pH-Responsiveness, Cellular Trafficking, Cytotoxicity and Long-circulation of PEGylated Liposomes with Post-insertion Technique Using Gemcitabine as a Model Drug. Pharm Res. 2015 Jul;32(7):2428-38.
Molecular Weight
– 2000(Average)
Compound Purity
– 95.0
SMILES
– CCCCCCCC/C=CCCCCCCCC(OC[C@@H](OC(CCCCCCC/C=CCCCCCCCC)=O)COP(OCCNC(OCCOC)=O)(O)=O)=O.[n]
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Liposome
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
