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Domperidone-d6

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Products Details

Product Description

– Domperidone-d6 is the deuterium labeled Domperidone. Domperidone (R33812) is a selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1][2].

Web ID

– HY-B0411S

Shipping

– Room temperature

Applications

– Neuroscience-Neuromodulation

Molecular Formula

– C22H18D6ClN5O2

References

– [1]Reddymasu SC, et al. Domperidone: review of pharmacology and clinical applications in gastroenterology. Am J Gastroenterol. 2007;102(9):2036-2045.|[2]Champion MC, et al. Domperidone, a new dopamine antagonist. CMAJ. 1986;135(5):457-461.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

CAS Number

– 1329614-18-7

Molecular Weight

– 431.95

SMILES

– O=C1N(C=2C(N1)=CC(Cl)=CC2)C3CCN(C(C(C(N4C=5C(NC4=O)=CC=CC5)([2H])[2H])([2H])[2H])([2H])[2H])CC3

Clinical Information

– No Development Reported

Research Area

– Neurological Disease

Solubility

– 10 mM in DMSO

Target

– Dopamine Receptor;Isotope-Labeled Compounds

Pathway

– GPCR/G Protein;Neuronal Signaling;Others

Product type

– Isotope-Labeled Compounds

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

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