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Products Details
Product Description
– DNA-PK-IN-8 is a highly potent, selective and orally active DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of 0.8 nM. DNA-PK-IN-8 exhibits synergistic antiproliferative activity against a series of cancer cell lines and significantly suppresses HL-60 tumor growth, when using in combination with Doxorubicin[1].
Web ID
– HY-146565
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C19H22N8O2
References
– [1]Ding Z, et al. Discovery of novel 7,8-dihydropteridine-6(5H)-one-based DNA-PK inhibitors as potential anticancer agents via scaffold hopping strategy. Eur J Med Chem. 2022;237:114401.
CAS Number
– 2823369-81-7
Molecular Weight
– 394.43
SMILES
– CC1=CC2=NC=NN2C=C1NC3=NC=C4C(N(CC(N4C)=O)C5CCOCC5)=N3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– DNA-PK
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Product type
– Reference compound
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