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DNA-PK-IN-6

SKU HY-144039-Get quote Category Tags , ,

Products Details

Product Description

– DNA-PK-IN-6 is a potent inhibitor of DNA-PK. DNA-PK-IN-6 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-6 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021197159A1, compound 6)[1].

Web ID

– HY-144039

Shipping

– Room temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C19H21N7O

References

– [1]Xinhai Chen, et al. Macrocyclic compounds as dna-pk inhibitors. Patent WO2021197159A1.

CAS Number

– 2711810-41-0

Molecular Weight

– 363.42

SMILES

– O=C1N(C)C2=C(N3)N1CCCCCC4=CN=C(C=C5C)N4C=C5/N=C3/N=C2

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– DNA-PK

Pathway

– Cell Cycle/DNA Damage;PI3K/Akt/mTOR

Product type

– Reference compound

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

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