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Products Details
Product Description
– DNA Gyrase-IN-9 (compound 4j) is an antibacterial agent that targets DNA gyrase. The MIC to inhibit Gram bacteria is 0.5-2 μg/mL, and the MBC to kill Gram bacteria is 2-8 μg/mL. DNA Gyrase-IN-9 inhibits DNA gyrase in Staphylococcus aureus with IC50=6.29 μg/mL[1].
Web ID
– HY-149534
Shipping
– Room temperature
Molecular Formula
– C26H18ClN3O2
References
– [1]Almaghrabi M, et al. Introducing of novel class of pyrano [2, 3-c] pyrazole-5-carbonitrile analogs with potent antimicrobial activity, DNA gyrase inhibition, and prominent pharmacokinetic and CNS toxicity profiles supported by molecular dynamic simulation[J]. Journal of Biomolecular Structure and Dynamics, 2023: 1-18.. . .
Molecular Weight
– 439.89
SMILES
– N#CC(C1C2=CC=C(C3=CC=CC=C3)C=C2)=C(O)OC4=C1C(C)=NN4C5=CC=C(Cl)C=C5
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Bacterial;DNA/RNA Synthesis
Pathway
– Anti-infection;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
