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Products Details
Product Description
– Antibacterial agent 138 is a benzothiazole inhibitor of bacterial DNA gyrase and topoisomerase IV. Antibacterial agent 138 exhibits favorable solubility and plasma protein binding. Antibacterial agent 138 has antibacterial activity against Gram-positive and Gram-negative strains. Antibacterial agent 138 is a dual GyrB and ParE inhibitor[1].
Web ID
– HY-149925
Shipping
– Room temperature
Molecular Formula
– C18H16Cl2N4O4S
References
– [1]Durcik M, et al. New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus. J Med Chem. 2023 Mar 23;66(6):3968-3994.
Molecular Weight
– 455.32
SMILES
– CC1=C(C(Cl)=C(N1)C(NC2=NC3=C(S2)C=C(C=C3N4CCOCC4)C(O)=O)=O)Cl
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Bacterial;DNA/RNA Synthesis;Topoisomerase
Pathway
– Anti-infection;Cell Cycle/DNA Damage
Product type
– Reference compound
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