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Products Details
Product Description
– Divin, a potent chelator of iron, is a potent inhibitor of bacterial cell division with bacteriostatic effect in Gram-negative and Gram-positive bacteria. Divin disrupts the assembly of late division proteins, reduces peptidoglycan remodeling at the division site, and blocks compartmentalization of the cytoplasm[1][2][3].
Web ID
– HY-124712
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H20N4O2
References
– [1]Maoquan Zhou, et al. Structure-activity studies of divin: an inhibitor of bacterial cell division. ACS Med Chem Lett. 2013 Sep 12;4(9):880-885.|[2]Ye-Jin Eun, et al. Divin: a small molecule inhibitor of bacterial divisome assembly. J Am Chem Soc. 2013 Jul 3;135(26):9768-76.|[3]Thiago M A Santos, et al. Small Molecule Chelators Reveal That Iron Starvation Inhibits Late Stages of Bacterial Cytokinesis. ACS Chem Biol. 2018 Jan 19;13(1):235-246.
CAS Number
– 1443321-11-6
Molecular Weight
– 372.42
SMILES
– O=C(N/N=C/C1=C2C=CC=CC2=CC=C1O)CCN3C4=CC=CC=C4N=C3C
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Bacterial
Pathway
– Anti-infection
Product type
– Reference compound
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