Download Files:
Products Details
Product Description
– Disulfamide, an orally active diuretic, is a carbonic anhydrase inhibitor with the IC50 value of 0.07 μM. Disulfamide leads to diuresis by inhibiting carbonic anhydrase and preventing the reabsorption of sodium and bicarbonate in the proximal tubule[1].
Web ID
– HY-137364
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C7H9ClN2O4S2
References
– [1]CT Supuran, et al. Carbonic anhydrase inhibitors: Synthesis and inhibitory properties of 1,3,4-thiadiazole-2,5-bissulfonamide. European Journal of Medicinal Chemistry,Volume 31, Issue 11, 1996, Pages 843-846.|[2]J M Foy, et al. Acute diuretic induced hyperglycaemia in rats. Life Sci. 1967 May 1;6(9):897-902.
CAS Number
– 671-88-5
Molecular Weight
– 284.74
SMILES
– O=S(C1=C(C)C=C(Cl)C(S(=O)(N)=O)=C1)(N)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Carbonic Anhydrase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
