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Products Details
Product Description
– Distamycin A (NSC-82150), an oligopeptide antibiotic, is a minor groove binder which binds to B-form DNA, preferentially at A/T rich sites.Distamycin A can change Enediyne-induced DNA cleavage sites and enhances apoptosis[1][2][3].
Web ID
– HY-112058
Shipping
– Room temperature
Molecular Formula
– C22H27N9O4
References
– [1]ARCAMONE F, et, al. STRUCTURE AND SYNTHESIS OF DISTAMYCIN A. Nature. 1964 Sep 5;203:1064-5.|[2]Hiraku Y, et, al. Distamycin A, a minor groove binder, changes enediyne-induced DNA cleavage sites and enhances apoptosis. Nucleic Acids Res Suppl. 2002;(2):95-6. |[3]Majumder P, et, al. Effect of DNA groove binder distamycin A upon chromatin structure. PLoS One. 2011;6(10):e26486.
CAS Number
– 636-47-5
Molecular Weight
– 481.51
SMILES
– O=C(C1=CC(NC(C2=CC(NC=O)=CN2C)=O)=CN1C)NC3=CN(C)C(C(NCCC(N)=N)=O)=C3
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Apoptosis
Pathway
– Anti-infection;Apoptosis
Product type
– Reference compound
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