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Diphenidol (hydrochloride)
SKU
HY-A0082-100 mg
Category Reference compound
Tags GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling, mAChR;Sodium Channel, Neurological Disease
$60 – $66
Products Details
Product Description
– Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol hydrochloride is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells[1][2].
Web ID
– HY-A0082
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C21H28ClNO
References
– [1]Leung YM, et al. Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. Pharmacol Rep. 2012;64(3):739-44.|[2]Leung YM, et al. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58(7):1147-52.|[3]Andersson M, et al. Muscarinic receptor subtypes involved in urothelium-derived relaxatory effects in the inflamed rat urinary bladder. Auton Neurosci. 2012 Sep 25;170(1-2):5-11.
CAS Number
– 3254-89-5
Molecular Weight
– 345.91
Compound Purity
– 99.95
SMILES
– OC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCCCC3.[H]Cl
Clinical Information
– Launched
Research Area
– Neurological Disease
Solubility
– DMSO : ≥ 46 mg/mL|H2O : 16.67 mg/mL (ultrasonic)
Target
– mAChR;Sodium Channel
Isoform
– mAChR1;mAChR2;mAChR3;mAChR4
Pathway
– GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
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