Dinactin

$996

Only 1000 item(s) left in stock.

Products Details

Product Description

– Dinactin, an antibiotic ionophore produced by Streptomyces species, as an effective small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Dinactin shows marked inhibition of HCT-116 cell growth with an IC50 of 1.1 µM. Dinactin shows anti-proliferative activity against the cancer cells in apoptosis-independent manner. Dinactin is also an effective agent for the research of neuropathic pain[1].

Web ID

– HY-121333

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C42H68O12

References

– [1]Aehtesham Hussain, et al. Identification of dinactin, a macrolide antibiotic, as a natural product-based small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Cancer Chemother Pharmacol. 2019 Sep;84(3):551-559.

CAS Number

– 20261-85-2

Molecular Weight

– 764.98

SMILES

– CC[C@@H](OC([C@@H]([C@H]1O[C@@](C[C@@H](OC([C@H]([C@@](CC2)([H])O[C@@]2([H])C3)C)=O)C)([H])CC1)C)=O)C[C@]4([H])O[C@@]([C@@H](C(O[C@H](C[C@@]5([H])O[C@H]([C@H](C(O[C@@H]3CC)=O)C)CC5)C)=O)C)([H])CC4

Clinical Information

– No Development Reported

Research Area

– Cancer; Neurological Disease; Infection

Solubility

– 10 mM in DMSO

Target

– Antibiotic;Wnt;β-catenin

Pathway

– Anti-infection;Stem Cell/Wnt

Product type

– Natural Products

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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