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Products Details
Product Description
– Dimethomorph-d8 is the deuterium labeled Dimethomorph[1]. Dimethomorph is a fungicide belongs to the fungicide group of sterol biosynthesis inhibitor. Dimethomorph can inhibit fungal cell wall formation. Dimethomorph also inhibits androgen receptor (AR) activity in MDA-kb2 cells with an IC20 of 0.263 μM[2][3][4].
Web ID
– HY-B0846S
Shipping
– Room temperature
Molecular Formula
– C21H14D8ClNO4
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]M E Matheron, et al. Impact of Azoxystrobin, Dimethomorph, Fluazinam, Fosetyl-Al, and Metalaxyl on Growth, Sporulation, and Zoospore Cyst Germination of Three Phytophthora spp. Plant Dis. 2000 Apr;84(4):454-458.|[3]Frances Orton, et al. Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogens. Environ Health Perspect. 2011 Jun119(6):794-800.|[4]Yigal Cohen,, et al. Differential Activity of Carboxylic Acid Amide Fungicides Against Various Developmental Stages of Phytophthora infestans. Phytopathology. 2007 Oct97(10):1274-83.
CAS Number
– 1346606-71-0
Molecular Weight
– 395.91
SMILES
– O=C(N1C([2H])([2H])C([2H])([2H])OC([2H])([2H])C1([2H])[2H])/C=C(C2=CC=C(C=C2)Cl)C3=CC(OC)=C(C=C3)OC
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Androgen Receptor;Fungal;Parasite
Pathway
– Anti-infection;Vitamin D Related/Nuclear Receptor
Product type
– Isotope-Labeled Compounds
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