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Products Details
Product Description
– Dim16 is a dual PCSK9/HMG-CoAR inhibitor, with an IC50 value of 19 nM for PCSK9. Dim16 inhibits PCSK9-LDLR binding with an IC50 value of 0.8 nM. Dim16 increases LDL uptake in HepG2 cells[1].
Web ID
– HY-149310
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C29H38IN5
References
– [1]Lammi C, et al. Computational Design, Synthesis, and Biological Evaluation of Diimidazole Analogues Endowed with Dual PCSK9/HMG-CoAR-Inhibiting Activity. J Med Chem. 2023 Jun 22;66(12):7943-7958.
CAS Number
– 2743448-32-8
Molecular Weight
– 583.55
SMILES
– CC(C)(C)CCCN1C(C2=CN=C(N2CCCCCNC)I)=NC=C1C3=CC=C4C=CC=CC4=C3
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Ser/Thr Protease
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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