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Product Description
– Dihydrexidine (DAR-0100) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist with an IC50 of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity[1][2][3][4]. Dihydrexidine can stimulate YAP phosphorylation[5].
Web ID
– HY-101299A
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C17H17NO2
References
– [1]Lovenberg TW, et al. Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist. Eur J Pharmacol. 1989 Jul 4;166(1):111-3.|[2]Mottola DM, et al. Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. J Pharmacol Exp Ther. 1992 Jul;262(1):383-93.|[3]Salmi P,et al. Dihydrexidine–the first full dopamine D1 receptor agonist. CNS Drug Rev. 2004 Fall;10(3):230-42.|[4]Gleason, S. D., et al. Effects of dopamine D1 receptor agonists in rats trained to discriminate dihydrexidine. Psychopharmacology, 2006;186(1), 25–31.|[5]Yu FX, et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012;150(4):780-791.
CAS Number
– 123039-93-0
Molecular Weight
– 267.32
SMILES
– OC1=C(O)C=C(CC[C@]2([H])[C@]3([H])C4=C(C=CC=C4)CN2)C3=C1
Clinical Information
– Phase 1
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Dopamine Receptor
Isoform
– D1 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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