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Products Details
Product Description
– Diflunisal-d3 is the deuterium labeled Diflunisal. Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.
Web ID
– HY-18342S
Shipping
– Room temperature
Molecular Formula
– C13H5D3F2O3
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Lin JH, et al. Dose-dependent pharmacokinetics of diflunisal in rats: dual effects of protein binding and metabolism. J Pharmacol Exp Ther. 1985 Nov;235(2):402-6.|[3]Winter CA, et al. Analgesic activity of diflunisal [MK-647; 5-(2,4-difluorophenyl)salicylic acid] in rats with hyperalgesia induced by Freund’s adjuvant. J Pharmacol Exp Ther. 1979 Dec;211(3):678-85.|[4]Cappon GD, et al. Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure. Birth Defects Res B Dev Reprod Toxicol. 2003 Feb;68(1):47-56.
CAS Number
– 1286107-99-0
Molecular Weight
– 253.22
SMILES
– O=C(C1=C(O)C([2H])=C([2H])C(C2=CC=C(C=C2F)F)=C1[2H])O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Cancer
Solubility
– 10 mM in DMSO
Target
– COX;Isotope-Labeled Compounds
Pathway
– Immunology/Inflammation;Others
Product type
– Isotope-Labeled Compounds
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