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Products Details
Product Description
– DIDS is a potent RAD51 inhibitor. DIDS inhibits the RAD51-mediated homologous pairing and strand-exchange reactions. DIDS inhibits anion exchange and binding to the red blood cell membrane[1][2].
Web ID
– HY-121693
Shipping
– Room temperature
Molecular Formula
– C16H10N2O6S4
Citations
– Cell Death Discov. 2023 Jul 8;9(1):234.|Adv Sci (Weinh). 2021 Nov;8(21):e2101936.|Autophagy. 2021 Nov;17(11):3592-3606.|Biochem Biophys Res Commun. 2021 May.|bioRxiv. 2023 Jul 3.|Cancer Sci. 2020 Nov;111(11):4288-4302.|FEBS Open Bio. 2021 Dec 30.|J Cell Mol Med. 2021 May 5.|Life Sci. 2020 Oct 15;259:118390.|SSRN. 2023 Nov 14.
References
– [1]Ishida T, et, al. DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange. Nucleic Acids Res. 2009 Jun;37(10):3367-76.|[2]Lepke S, et, al. A study of the relationship between inhibition of anion exchange and binding to the red blood cell membrane of 4,4′-diisothiocyano stilbene-2,2′-disulfonic acid (DIDS) and its dihydro derivative (H2DIDS). J Membr Biol. 1976 Oct 20;29(1-2):147-77.
CAS Number
– 53005-05-3
Molecular Weight
– 454.52
SMILES
– O=S(C1=CC(N=C=S)=CC=C1/C=C/C2=CC=C(C=C2S(=O)(O)=O)N=C=S)(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– RAD51
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
