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Dicyclomine (hydrochloride)
$30 – $50
Products Details
Product Description
– Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively[1]. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo[2].
Web ID
– HY-B1339
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C19H36ClNO2
References
– [1]J Pavía,et al. Pharmacological Characterization and Distribution of Muscarinic Receptors in Human Placental Syncytiotrophoblast Brush-Border and Basal Plasma Membranes. Eur J Pharmacol. . 1997 Feb 12;320(2-3):209-14.|[2]Antonella Caccamo, et al. M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice. 2006 Mar 2;49(5):671-82.doi: 10.1016/j.neuron.2006.01.020.|[3]Susan J Bartko,et al. A Computer-Automated Touchscreen Paired-Associates Learning (PAL) Task for Mice: Impairments Following Administration of Scopolamine or Dicyclomine and Improvements Following Donepezil.Psychopharmacology (Berl). 2011 Mar;214(2):537-48.
CAS Number
– 67-92-5
Molecular Weight
– 345.95
Compound Purity
– 98.0
SMILES
– O=C(C1(C2CCCCC2)CCCCC1)OCCN(CC)CC.[H]Cl
Clinical Information
– Launched
Research Area
– Neurological Disease
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Target
– mAChR
Isoform
– mAChR1;mAChR2
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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