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Product Description
– Dictyostatin ((-)-Dictyostatin; Dictyostatin 1) is a potent microtubule stabilizing agent. Dictyostatin also is a anti-cancer agent. Dictyostatin shows antiproliferative activity. Dictyostatin has the potential for the research of tauopathies[1][2][3].
Web ID
– HY-N10660
Shipping
– Room temperature
Molecular Formula
– C32H52O6
References
– [1]Makani V, et al. Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy. Acta Neuropathol Commun. 2016 Sep 29;4(1):106.|[2]George R. Pettit, et al. Isolation and structure of the cancer cell growth inhibitor dictyostatin 1. J. Chem. Soc., Chem. Commun., 1995, 2373-2670.|[3]Vollmer LL, et al. A simplified synthesis of novel dictyostatin analogues with in vitro activity against epothilone B-resistant cells and antiangiogenic activity in zebrafish embryos. Mol Cancer Ther. 2011 Jun;10(6):994-1006.
CAS Number
– 156312-07-1
Molecular Weight
– 532.75
SMILES
– C=C/C=C[C@@H]([C@@]1([H])[C@H]([C@@H](CC[C@@H](C[C@@H]([C@H]([C@H](/C=C/[C@H](C[C@@H]([C@@H](/C=C/C=C/C(O1)=O)C)O)O)C)O)C)C)O)C)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
