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diABZI STING agonist-1 (trihydrochloride)
$214 – $3,840
Products Details
Product Description
– diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
Web ID
– HY-112921B
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C42H54Cl3N13O7
Citations
– ACS Infect Dis. 2022 Feb 8.|Am J Cancer Res. 2023 May 30;13(5):2055-2065.|Cancer Lett. 20 August 2022, 215885.|Cell Death Dis. 2022 Jul 28;13(7):653.|Cell Immunol. 2021, 104384.|Front Immunol. 2020 Jul 8;11:1430.|Front Pharmacol. 2023 Apr 4;14:1160445.|J Invest Dermatol. 2021 Sep 24;S0022-202X(21)02227-2.|Mol Cell. 2023 Apr 14;S1097-2765(23)00243-5.|Nat Nanotechnol. 2021 Sep 30.|OncoImmunology. 2022 Feb 1;11(1):2030021.|PLoS One. 2021 Oct 27;16(10):e0258989.|Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2213777120.|Protein Cell. 2021 Oct 22;1-21.|Sci Rep. 2022 Oct 24;12(1):17827.|Thorac Cancer. 2022 May; 13(9): 1361–1368.|Cell Death Differ. 2023 Nov 25.|Genes Dis. 2023 Sep 2.|University of California San Diego. 2023|Cell Res. 2022 Dec;32(12):1086-1104.|Data in Brief. 2022: 108743.
References
– [1]Ramanjulu JM, et al. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature. 2018 Nov 7.
CAS Number
– 2138299-34-8
Molecular Weight
– 959.32
Compound Purity
– 99.92
SMILES
– O=C(C1=CC(C)=NN1CC)NC2=NC3=CC(C(N)=O)=CC(OC)=C3N2C/C=C/CN4C5=C(OCCCN6CCOCC6)C=C(C(N)=O)C=C5N=C4NC(C7=CC(C)=NN7CC)=O.Cl.Cl.Cl
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Cancer
Solubility
– DMSO : 90 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic)
Target
– STING
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
