Download Files:
Products Details
Product Description
– DHODH-IN-3 (compound 3) is a potent inhibitor of Human Dihydroorotate Dehydrogenases (HsDHODH) with an IC50 value of 261 nM. DHODH-IN-3 binds to the the ubiquinone binding cavities in DHODH with a Kiapp of 32 nM. DHODH-IN-3 has the potential for malaria treatment[1].
Web ID
– HY-135618
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C17H13ClN2O2
References
– [1]Davies M, et al. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.J Med Chem. 2009 May 14;52(9):2683-93.
CAS Number
– 1148126-04-8
Molecular Weight
– 312.75
SMILES
– C/C(O)=C(C#N)/C(NC1=CC=C(C2=CC=CC=C2)C=C1Cl)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Dihydroorotate Dehydrogenase;DNA/RNA Synthesis
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
