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Products Details
Product Description
– DHODH-IN-21 (compound 19) is an orally active selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 value of 1.1 nM. DHODH-IN-21 has anticancer activity and can be used in studies of acute myeloid leukaemia (AML)[1].
Web ID
– HY-149030
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H19ClF4N6O4
References
– [1]Justin S Cisar, et al. N-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia. J Med Chem. 2022 Aug 4.
CAS Number
– 2450341-39-4
Molecular Weight
– 518.85
SMILES
– O=C1N(C2=C(F)C=C(C(NC3=C(Cl)N=CC=C3C)=O)C(O[C@@H](C)C(F)(F)F)=N2)N=C(N1CC)CO
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Dihydroorotate Dehydrogenase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
