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Products Details
Product Description
– DHFR-IN-1 (compound 12) is a potent and selective DHFR (dihydrofolate reductase)inhibitor, with an IC50 of 40.71 nM. DHFR-IN-1 exhibits promising antibacterial activity against gram-positive and gram-negative bacteria. DHFR-IN-1 exhibits moderate antifungal activities. DHFR-IN-1 exhibits a high synergistic effect with Levofloxacin (HY-B0330), where the FIC (fractional inhibitory concentration index) value is 0.249[1].
Web ID
– HY-143236
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H22N6O4S2
References
– [1]Alzahrani AY, et al. Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm activities with molecular modelling study. Bioorg Chem. 2022 Feb;119:105571.
CAS Number
– 2757991-65-2
Molecular Weight
– 498.58
SMILES
– CN1CCN(CC1)S(=O)(C2=CC=C3NC(/C(C3=C2)=NNC4=NC(C5=CC=C(C=C5)O)=CS4)=O)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Bacterial;Fungal
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
