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DH-376
SKU
HY-120171-Get quote
Category Reference compound
Tags MAGL, Metabolic Disease, Metabolic Enzyme/Protease
Products Details
Product Description
– DH-376 is a potent diacylglycerol lipase inhibitor with pIC50 values of 8.6 and 8.9 for ABHD6 and DAGLα, respectively. DH-376 prevents fasting-induced refeeding of mice[1]. DH-376 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-120171
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C31H28F2N4O3
References
– [1]Deng H, et, al. Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding. J Med Chem. 2017 Jan 12;60(1):428-440.
CAS Number
– 1848233-57-7
Molecular Weight
– 542.58
SMILES
– O=C(N1N=CC(C(C2=CC=C(F)C=C2)(C3=CC=C(F)C=C3)O)=N1)N4[C@@H](CC5=CC=CC=C5)CC[C@@H](OCC#C)C4
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– MAGL
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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