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Products Details
Product Description
– DG1 (Compound 8Nc) is a Thymidylate Synthase (TS) inhibitor that affects cancer angiogenesis and metabolic reprogramming in NSCLC cells. DG1 can effectively inhibit the expression of CD26, ET-1, FGF-1 and EGF. DG1 also effectively inhibits the proliferation of cancer tissue in the A549 xenograft mouse model[1].
Web ID
– HY-149352
Shipping
– Room temperature
Molecular Formula
– C19H17N5O5S
References
– [1]Dong G, et al. Discovery of novel thymidylate synthase (TS) inhibitors that influence cancer angiogenesis and metabolic reprogramming in NSCLC cells. Eur J Med Chem. 2023 Oct 5;258:115600.
Molecular Weight
– 427.43
SMILES
– O=C1NC(NC=C1S(=O)(NC2=CC=CC(C(N/N=C/C3=CC(C)=CC=C3)=O)=C2)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Thymidylate Synthase
Pathway
– Apoptosis
Product type
– Reference compound
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