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Dexmedetomidine (hydrochloride)
$55 – $198
Products Details
Product Description
– Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects[1][2][3].
Web ID
– HY-17034A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C13H17ClN2
Citations
– Eur J Neurosci. 2021 Nov 4.|Hum Exp Toxicol. 2021 Dec;40(12):2145-2155.|Nat Commun. 2023 Jul 7;14(1):4011.|Pharmacology. 2021 Oct 29;1-14.|Biomed Pharmacother. 2023 Nov 23:169:115915.|Cardiovasc Drugs Ther. 2023 Jul 1.|J Neuropathol Exp Neurol. 2022 Jul 11;nlac055.|J Toxicol Sci. 2023;48(3):139-148.|Molecular Cellular Toxicology. 2023 Jun 2.
References
– [1]Virtanen R, et, al. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol. 1988 May 20;150(1-2):9-14.|[2]Gertler R, et, al. Dexmedetomidine: a novel sedative-analgesic agent. Proc (Bayl Univ Med Cent). 2001 Jan;14(1):13-21.|[3]Sajid B, et, al. A comparison of oral dexmedetomidine and oral midazolam as premedicants in children. J Anaesthesiol Clin Pharmacol. Jan-Mar 2019;35(1):36-40.
CAS Number
– 145108-58-3
Molecular Weight
– 236.74
Compound Purity
– 99.93
SMILES
– C[C@H](C1=CN=CN1)C2=CC=CC(C)=C2C.Cl
Clinical Information
– Launched
Research Area
– Neurological Disease; Endocrinology; Cancer
Solubility
– DMSO : 250 mg/mL (ultrasonic)|H2O : ≥ 50 mg/mL
Target
– Adrenergic Receptor
Isoform
– α adrenergic receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
