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Products Details
Product Description
– Dexamethasone oxetanone (Dex-Ox), a derivative of the glucocorticoid-selective steroid Dexamethasone (Dex), is an antiglucocorticoid. Dexamethasone oxetanone is an antiprogestin with significant agonist activity with progesterone receptor (PR) A and B isoforms[1][2].
Web ID
– HY-147220
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C22H27FO4
References
– [1]D Gagne, et al. Analysis of the relation between receptor binding affinity and antagonist efficacy of antiglucocorticoids. J Steroid Biochem. 1986 Sep;25(3):315-22.|[2]G Giannoukos, et al. New antiprogestins with partial agonist activity: potential selective progesterone receptor modulators (SPRMs) and probes for receptor- and coregulator-induced changes in progesterone receptor induction properties. Mol Endocrinol. 2001 Feb;15(2):255-70.
CAS Number
– 4089-36-5
Molecular Weight
– 374.45
SMILES
– C[C@@]12[C@@]3(C(CO3)=O)[C@@H](C[C@@]1([H])[C@@]4([H])[C@]([C@H](C2)O)([C@@]5(C(CC4)=CC(C=C5)=O)C)F)C
Clinical Information
– No Development Reported
Research Area
– Endocrinology
Solubility
– 10 mM in DMSO
Target
– Progesterone Receptor
Pathway
– Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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