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Desmethyl cariprazine
SKU
HY-100656-10 mg
Category Reference compound
Tags 5-HT Receptor;Dopamine Receptor;Drug Metabolite, GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling, Neurological Disease
$480 – $3,940
Products Details
Product Description
– Desmethyl cariprazine is an active metabolite of Cariprazine[1]. Cariprazine, an antipsychotic agent candidate, exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM)[2].
Web ID
– HY-100656
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C20H30Cl2N4O
References
– [1]Campbell RH, et al. Review of cariprazine in management of psychiatric illness. Ment Health Clin. 2018 Mar 23;7(5):221-229.|[2]Seneca N, et al. Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology (Berl). 2011 Dec;218(3):579-8.
CAS Number
– 839712-15-1
Molecular Weight
– 413.38
Compound Purity
– 98.06
SMILES
– O=C(NC)N[C@@H]1CC[C@@H](CCN2CCN(C3=CC=CC(Cl)=C3Cl)CC2)CC1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 5 mg/mL (ultrasonic;warming;heat to 80°C)
Target
– 5-HT Receptor;Dopamine Receptor;Drug Metabolite
Isoform
– 5-HT1 Receptor;D2 Receptor;D3 Receptor
Pathway
– GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
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