Download Files:
Desloratadine
$58 – $515
Products Details
Product Description
– Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].
Web ID
– HY-B0539
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H19ClN2
References
– [1]Geha, R.S. and E.O. Meltzer, Desloratadine: A new, nonsedating, oral antihistamine. J Allergy Clin Immunol, 2001. 107(4): p. 751-62.|[2]Schroeder, J.T., et al., Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. Clin Exp Allergy, 2001. 31(9): p. 1369-77.|[3]Anthes, J.C., et al., Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor. Eur J Pharmacol, 2002. 449(3): p. 229-37.|[4]McClellan K, et al. Desloratadine. Drugs. 2001;61(6):789-797.
CAS Number
– 100643-71-8
Molecular Weight
– 310.82
Compound Purity
– 99.98
SMILES
– ClC1=CC=C2C(CCC3=CC=CN=C3/C2=C4CCNCC/4)=C1
Clinical Information
– Launched
Research Area
– Inflammation/Immunology; Endocrinology; Cancer
Solubility
– DMSO : 25 mg/mL (ultrasonic)|H2O : 0.67 mg/mL (ultrasonic)
Target
– Endogenous Metabolite;Histamine Receptor
Isoform
– H1 Receptor;Human Endogenous Metabolite
Pathway
– GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
