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Product Description
– Desipramine is a tricyclic psychotic compound, possessing antidepressant activity. Desipramine inhibits the norepinephrine reuptake receptor in the central nervous system and reduces the sleep-related loss of genioglossus activity, can be used to research the improvement of pharyngeal collapsibility[1][2].
Web ID
– HY-B1272A
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C18H22N2
Citations
– Research Square Print. 2023 Feb 23.|Biochim Biophys Acta Mol Basis Dis. 2023 Mar 28;1869(5):166700.|Glia. 2022 Jul 1.|Inflammation. 2021 Mar 4.|J Parkinson Dis. 2020;10(2):523-542.|Neural Regen Res. 2021;16:1660-70.|Neurotoxicology. 2022 Oct 6;S0161-813X(22)00156-5.|Parkinsons Dis-us. 2022.|Pharmaceutics. 2022, 14(8), 1523.
References
– [1]Garcia AS, et al. Autoreceptor-mediated inhibition of norepinephrine release in rat medial prefrontal cortex is maintained after chronic desipramine treatment. J Neurochem. 2004 Nov;91(3):683-93.|[2]Taranto-Montemurro L, et al. Desipramine improves upper airway collapsibility and reduces OSA severity in patients with minimal muscle compensation. Eur Respir J. 2016 Nov;48(5):1340-1350.
CAS Number
– 50-47-5
Molecular Weight
– 266.38
SMILES
– CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31
Clinical Information
– Launched
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Adrenergic Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
