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Product Description
– Desethyl chloroquine-d4 is the deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].
Web ID
– HY-135811S
Shipping
– Room temperature
Molecular Formula
– C16H18D4ClN3
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18(2):95-100.|[3]Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3(2):159-74.|[4]Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43.
CAS Number
– 1189971-72-9
Molecular Weight
– 295.84
SMILES
– CC(NC1=CC=NC2=CC(Cl)=CC=C12)CC([2H])([2H])C([2H])(NCC)[2H]
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Autophagy;Isotope-Labeled Compounds;Parasite;Toll-like Receptor (TLR)
Isoform
– Plasmodium
Pathway
– Anti-infection;Autophagy;Immunology/Inflammation;Others
Product type
– Isotope-Labeled Compounds
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