Download Files:
Denifanstat
$250 – $1,150
Products Details
Product Description
– Denifanstat (TVB-2640) is an orally active and potent Fatty Acid Synthase (FASN) inhibitor with an IC50 of 0.052 μM and an EC50 of 0.072 μM. Denifanstat has the potential for fatty liver disease and cancer research[1][2].
Web ID
– HY-112829
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Molecular Formula
– C27H29N5O
References
– [1]Johan D., et al. Heterocyclic modulators of lipid synthesis. WO2012122391A1.|[2]Minhyoung Lee, et al. Fatty Acid Synthase inhibition prevents palmitoylation of SARS-CoV2 Spike Protein and improves survival of mice infected with murine hepatitis virus. BioRxiv, December 21, 2020.
CAS Number
– 1399177-37-7
Molecular Weight
– 439.55
Compound Purity
– 99.69
SMILES
– N#CC1=CC=C(C2CCN(C(C3=CC(C4=NC(C)=NN4)=C(C5CCC5)C=C3C)=O)CC2)C=C1
Clinical Information
– Phase 3
Research Area
– Cancer; Metabolic Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Fatty Acid Synthase (FASN)
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
