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Delavirdine (mesylate)
SKU
HY-10571A-10 mg
Category Reference compound
Tags Anti-infection, HIV;Reverse Transcriptase, Infection
$41 – $185
Products Details
Product Description
– Delavirdine (U 90152) mesylate is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine mesylate selectively inhibits HIV-1 reverse transcriptase (RT) (IC50=0.26 μM) over DNA polymerase α (IC50=440 μM) and polymerase δ (IC50>550 μM). Delavirdine mesylate is an inhibitor of HIV-1 replication and can can be used for the study of AIDs[1].
Web ID
– HY-10571A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C23H32N6O6S2
Citations
– Future Med Chem. 2018 Dec 17. |Int J Antimicrob Agents. 2019 Dec;54(6):814-819.|Sci Rep. 2015 Oct 29;5:15806.
References
– [1]Dueweke TJ, et al. U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob Agents Chemother. 1993 May;37(5):1127-31.|[2]Mayland Chang, et al. Metabolism of the HIV-1 Reverse Transcriptase Inhibitor Delavirdine In Mice. Research Article
CAS Number
– 147221-93-0
Molecular Weight
– 552.67
Compound Purity
– 99.82
SMILES
– O=S(NC1=CC=C(NC(C(N2CCN(C3=C(NC(C)C)C=CC=N3)CC2)=O)=C4)C4=C1)(C)=O.O=S(O)(C)=O
Clinical Information
– Launched
Research Area
– Infection
Solubility
– DMSO : ≥ 40.3 mg/mL
Target
– HIV;Reverse Transcriptase
Isoform
– HIV-1
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.